Evonik Silica improve the flow properties of starting materials for modern tablet and capsule manufacture and ensures rapid dissolution of the active ingredients. Suitable silica from Evonik is available for solid semi-solid and liquid dosage forms.

For the good of the patient: Silica from Evonik in the pharmaceutical industry


Many challenges – one solution: Fumed and precipitated silica from Evonik are some of the most important and highly used pharmaceutical excipients. Whether you manufacture medicines for solid, semi-solid or liquid dosing, we support you at every stage of product development.


Purity and reliability of raw materials are just two of the many challenges you face as a manufacturer of pharmaceutical products. If high-speed tablet and capsule production equipment, for example, is to run smoothly, the starting materials need to display optimum flow behavior. This is where our silica products come in: As flow aid, they ensure uniform active ingredient content in every tablet or capsule and increase production throughput.

And silica from Evonik can do much more: They can be used to reduce tablet weight without impacting stability. In pharmaceutical creams or viscous gels, they are used as thickening agents. Guaranteeing equal distribution of the active ingredient, these thickening and stabilizing properties are also beneficial when manufacturing active ingredient patches. 

Evonik offers a broad portfolio of silica products for the pharmaceutical industry based on more than five decades of experience. Together, we will find the ideal system solutions to make your products even more successful. You can find more information on our portfolio in our Produktfinder.

Benefits of silica from Evonik for the pharmaceutical industry

  • Stabilization of solid dispersions

  • Versatile carrier for liquid or poorly soluble active pharmaceutical ingredients (API)

  • Versatile auxiliary material for orally disintegrating tablets (ODT)

  • Adjustment of rheology in semi-solid medications

  • Improved dissolution of individual active ingredients

Video - Tableting with Moisture-Activated Dry Granulation

Silica from Evonik Regulatory Information

All AEROSIL® Pharma grades are manufactured according to IPEC GMP guidelines for bulk pharmaceutical excipients. Every lot is tested and certified according to compendial methods.

Compendial Compliance of Silica Products

Product

USP/NF

Ph. EUR.

JP

IP

AEROSIL® 200 Pharma

Colloidal silicon dioxide

Silica, colloidal anhydrous

Light anhydrous silicic acid

Silicon dioxide

AEROSIL® 300 Pharma

Colloidal silicon dioxide

Silica, colloidal anhydrous

Light anhydrous silicic acid

AEROSIL® 300 Pharma

Colloidal silicon dioxide

Silica, colloidal anhydrous

*

AEROSIL® R 972 Pharma

Hydrophobic colloidal silica

Silica, hydrophobic colloidal

No monograph

SIPERNAT® 160 PQ

Silicon dioxide

Silica colloidal hydrated

RXCIPIENTS® FM 1000

Calcium silicate

No monograph for calcium silicates.
EMA accepts compliance to USP/NF monographs for products for
which no Ph. Eur. monograph exists

ZEOPHARM® 600

Calcium silicate

No monograph for calcium silicates.
EMA accepts compliance to USP/NF monographs for products for
which no Ph. Eur. monograph exists

ZEOPHARM® 250 

Calcium silicate

No monograph for calcium silicates.
EMA accepts compliance to USP/NF monographs for products for
which no Ph. Eur. monograph exists

* Granulated AEROPERL® 300 Pharma does not fulfill the JP "Volume Test" due to its high bulk density

Brochures about silica
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YOU CAN FIND MORE INFORMATION ON OUR PORTFOLIO IN OUR PRODUCTFINDER
Productfinder Silica
FIELDS OF APPLICATION FOR SILICA IN THE Health Care INDUSTRY

Solid Dosage Forms - Sachets

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Semi-Solid Dosage Forms - Ointment

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Semi-Solid Dosage Forms - Transdermal

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Solid Dosage Forms - Capsules

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Semi-Solid Dosage Forms - Salves

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Semi-Solid Dosage Forms - Suppositories

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Solid Dosage Forms - Tablets

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Semi-Solid Dosage Forms - Creames

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